What is Armodafinil and How Does it Work?
What is Armodafinil?
Armodafinil is a wakefulness-promoting medication that promotes wakefulness in people suffering from extreme daytime sleepiness and is the enantiopure compound of Modafinil (a eugeroic).
Armodafinil is used by millions of people worldwide because of its multiple uses and benefits.
| Generic Armodafinil brand names | Artvigil and Waklert |
|---|---|
| Armodafinil drug class | Stimulant, wakefulness-promoting agent |
| Is Armodafinil a controlled substance? | Yes (C-IV), because it can lead to dependence |
| Armodafinil manufacturer | Teva Pharmaceutical Industries |
How Does Armodafinil Work?
Armodafinil mainly works by affecting various neurotransmitters (chemical messengers that allow neurons to communicate with one another throughout the body) such as histamine, dopamine, orexin, and norepinephrine, all of which promote alertness and wakefulness, and it restricts the action of GABA or Gamma-Aminobutyric Acid which triggers sleepiness when available in higher amounts.
Armodafinil Half-Life And How Long Does Armodafinil Last?
The half-life of Armodafinil is 15 hours, and it takes around 2-3 days for Armodafinil to leave the system completely.
How Long Does Armodafinil Take To Kick In?
Armodafinil begins to work or show its effects within 30 minutes of ingestion.
Armodafinil Uses And Benefits
Armodafinil Uses
Armodafinil was approved by the FDA in 2007 for the treatment of excessive sleepiness during the day associated with the following 3 conditions -
Narcolepsy
- Obstructive Sleep Apnea
- Shift Work Sleep Disorder
Narcolepsy is a long-term neurological disorder that causes extreme daytime sleepiness and is characterized by the inability to control the normal sleep-wake cycle.
Obstructive Sleep Apnea is a common sleep-related breathing disorder that causes recurring episodes of partial or complete obstruction of the upper airways, leading to absent or reduced breathing during sleep.
Shift Work Sleep Disorder is a sleep disorder characterized by excessive sleepiness, insomnia, or both, impacting people whose work hours overlap with the typical sleep schedule.
Off-label uses
The term off-label means prescribing medicines for health conditions that have not been approved by the FDA (Food And Drug Administration).
Armodafinil For Depression
Armodafinil is used to improve the symptoms of depression by promoting sunny thoughts, motivation, and excitement and by decreasing feelings of stress. Depression is a mood disorder that causes intense and long-lasting sadness and hopelessness.
Armodafinil For ADHD
Armodafinil is sometimes used to treat the symptoms of Attention Deficit Hyperactivity Disorder, a neurodevelopment disorder that includes a combination of persistent issues such as difficulty paying attention, hyperactivity, and impulsive behavior.
Armodafinil For Weight Loss
Armodafinil causes a loss of appetite as a side effect, which in turn results in weight loss in some individuals.
Armodafinil Dosage Guidelines
The standard dose of Armodafinil is 150 mg.
Armodafinil Dosage For Shift Work Sleep Disorder
For Shift Work Sleep disorders, Armodafinil 150 mg is administered once daily, 1 hour before work.
Armodafinil Dosage For Narcolepsy and Obstructive Sleep Apnea
For Narcolepsy and Obstructive Sleep Apnea, 150-250 mg of Armodafinil is administered once a day in the morning.
Armodafinil Dosage For ADHD
The suggested Armodafinil dosage for Attention Deficit Hyperactivity Disorder is 150 mg, taken in the morning.
Armodafinil Overdose
If Armodafinil is taken at a higher dose than the prescribed dose, it is advisable to consult a doctor. Some of the symptoms of an Armodafinil overdose are trouble sleeping, confusion, restlessness, chest pain, increased blood pressure, anxiety, shortness of breath, feeling excited, disoriented, hallucinations, and a fast or slow heartbeat.
Armodafinil warnings:
7 warnings of Armodafinil that patients should be aware of are as follows -
- Do not drive, or operate machinery because it could be dangerous until you are aware of how this medicine affects you.
- Talk to your doctor if you have been taking Armodafinil for a long time and feel that it is not working as well as before.
- People with liver and kidney diseases should use Armodafinil cautiously.
- Patients must ensure they are not allergic to any of the ingredients of Armodafinil.
- Individuals under the age of 18 should not take this medicine without consulting a healthcare provider.
- Pregnant and lactating women should not take Armodafinil without consulting a doctor.
- Patients with a history of mania, depression, psychosis or other psychiatric complications should seek prior medical consultation.
Armodafinil Side Effects
Common Side Effects
5 common side effects of Armodafinil tablets are
- Headache
- Dizziness
- Nausea
- Insomnia
- Loss of appetite
Armodafinil causes magnesium depletion, dehydration and works by functioning on the sympathetic nervous system to stimulate the brain, which results in headaches.
Armodafinil works by affecting the central nervous system, which, in turn, can cause dizziness.
Armodafinil can affect the gastrointestinal tract, resulting in nausea.
Armodafinil is a very powerful nootropic, and its effects last for a Flong time therefore, when it is taken during or close to bedtime, it can lead to insomnia.
Armodafinil reduces appetite considerably. A study states that, about 3% of their participants reported feeling decreased appetite.
5 Serious Side Effects Of Armodafinil
- Chest pain
- Mouth sores
- Anxiety
- Hallucination, mania, suicidal thoughts
- Blood pressure
In clinical studies, some of the symptoms of Armodafinil, including palpitation, chest pain, dyspnea, and transient T-waves, were observed in association with mitral valve prolapse or left ventricular hypertrophy. Therefore, it is recommended that Armodafinil not be used in patients with a history of cardiac problems in association with stimulant use.
Armodafinil can cause serious skin reactions such as bruising, ulcers, mouth sores, blistering, and skin rashes. Therefore, it is advised to consult a doctor if an individual experiences any skin reactions after taking the nootropic.
Armodafinil causes an over-activation of neurostimulating molecules such as serotonin, dopamine, and glutamate, which, as a result, can trigger anxiety.
Many psychiatric effects, such as delusion, hallucination, mania, aggression, and suicidal ideation, have been reported in patients treated with Armodafinil. Paranoid delusion, and auditory hallucinations have been reported in association with multiple daily 600 mg doses of Armodafinil.
Armodafinil may sometimes raise blood pressure in some people; therefore, increased monitoring of blood pressure in patients on Armodafinil is advised.
Long-term Effects of Armodafinil
Taking Armodafinil in the long term can cause psychological and physical dependence. The risk of dependence on Armodafinil is high in individuals who have a history of substance abuse.
Armodafinil Interactions
When administered with other drugs or supplements, Armodafinil interacts to increase the risk of side effects. It also lowers the potency of the medication, thus altering its therapeutic effectiveness.
Armodafinil 150 mg Drug Interaction
Artvigil 150 can interact with the following drugs (not a complete list), which can affect how the nootropic works.
Cyclosporine- Carbamazepine
- Diazepam
- Midazolam
- Omeprazole
- Propranolol
- Rifampin
- Blood thinner
- MAO inhibitor
- Clomipramine
- Phenobrabital
- Phenytoin
- Ketoconazole
- Erythromycin
Armodafinil And Caffeine
Caffeine is a central nervous system stimulant and is expected to be additive when coadministered with Armodafinil, and excessive intake of caffeine while taking Armodafinil may cause insomnia, nausea, nervousness, palpitation, and other side effects.
Armodafinil And Alcohol
Armodafinil medication and alcohol should not be coadministered. Armodafinil makes a patient more alert, whereas alcohol causes sleepiness, negating the effectiveness of the nootropic, and causes vomiting, confusion, blackouts, and a lack of coordination.
Armodafinil And Birth Control Pills
It's important to know that Armodafinil can make hormonal birth control pills less effective at preventing pregnancy therefore, talking to a doctor is important for using a backup.
It is important to note that taking any herbal medicines or vitamins with Armodafinil should be avoided.
Armodafinil Reviews
Customer reviews on the websites drugs.com and WebMD are as follows -
webmd.com
"This drug has been a miracle for me, I feel energetic during the day and can think clearly."drugs.com
"I was diagnosed with Narcolepsy and was prescribed Armodafinil. This medicine improved my quality of life drastically, and I was able to stay awake all day."drugs.com
"Taking Armodafinil for the last 8 years for Shift Work Sleep Disorder, and it has greatly improved my life, I am grateful to my doctor that he has prescribed me this medicine."drugs.com
"After 25 years of treatment for depression, Armodafinil relieved my symptoms in less than an hour. Now I have peace of mind, contentment, and the ability to enjoy life again."drugs.com
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FAQ
Armodafinil is a central nervous system stimulant that promotes wakefulness in people.
Armodafinil is a Schedule IV controlled substance.
Armodafinil takes 2 hours to reach its peak in the fasted state.
Armodafinil can be taken with or without food, but the nootropic takes longer to show its effects when taken with meals.
Taking Armodafinil too much can cause an overdose and can lead to unwanted side effects like chest pain, trouble sleeping, diarrhea, nausea, hallucination, confusion, or feeling restless and excited.