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How long does Armodafinil Stay in Your System

Author :

Abhishek Dutta

Post Uploaded Date : October 9, 2023 Last Updated Date : April 1, 2024
Armodafinil generally lasts for about 15 hours. However, the duration might vary from patient to patient. It might also take 2-3 days to remove the drug from your system completely.

Armodafinil is a drug that lasts longer than Modafinil ( a similar drug). Now, the question arises, How long does Armodafinil last? Here, you are at the right place to get the answer. 

Let’s go through the blog and glance at Armodafinil’s Half-life.

What is Armodafinil?

Armodafinil is the R-enantiomer of Modafinil that belongs to the Eugeroic group. It is a medication that helps treat Sleep disorders like Narcolepsy, Obstructive Sleep Apnea, and Shift Work Sleep disorder.

The Drug is a Scheduled IV Controlled Substance. The FDA approved the use of the medication in 2007.

It is sold under the brand names- Waklert and Artvigil. 

Teva Pharmaceuticals manufactures Armodafinil. 

What is Armodafinil Used For?

Armodafinil has three primary clinical uses-

  1. Narcolepsy– It is a chronic disorder associated with nerves that causes excessive sleepiness in the daytime and results in irregularities in the sleep cycle.

Armodafinil helps in regulating the sleep cycle.

  1. Obstructive Sleep Apnea– It blocks the air pathways that result in fragmentation of the Sleep Cycle. Armodafinil helps restore the sleep cycle.
  1. Shift Work Sleep Disorder is found among people who generally work for non-traditional hours. Armodafinil allows workers to stay active during working hours and maintain a proper sleep cycle.

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Besides, Armodafinil also has 5 notable off-label Uses. They are-

  1. Armodafinil for ADHD (attention deficit hyperactivity disorder) is a chronic condition marked by inactivity or impulsivity. 
  1. Armodafinil for Depression– This disorder makes mental changes and results in loss of pleasure or interest.
  2. Armodafinil for Anxiety is a feeling of fear, dreadfulness, and uneasiness.
  3. Armodafinil  Cognitive Enhancement– Cognitive Enhancement is also called neuroenhancer that enhances mood, focus, attention, etc.
  4. Armodafinil for Studying– Students use Armodafinil for studying as it is highly effective for increasing focus and memory. The medication also helps in staying awake to study and secure good marks in exams.

How does Armodafinil Work?

The Working Mechanism of Armodafinil is unclear; however, many researchers have found that Armodafinil works by changing the amount of Neurotransmitters like Histamine, Serotonin, Orexin, dopamine, etc. When inclined, the transmitters enhance focus, memory, and brain functioning.

How long does it take for Armodafinil to work?

Armodafinil takes 30-60 minutes to start its Onset of Action after ingesting it with a glass of water. It should be generally taken at the same time of the day for better effectiveness.

However, that varies from person to person [1].

The half-life of Armodafinil

 It is the period that medicine requires to reduce by half. Generally, it takes 4-5 half-lives to remove a medicine by 94-97 %. After 4-5 half-lives are eliminated, the plasma concentrations of a medicine decreases.

After reaching the peak plasma concentrations, the half-life of Armodafinil is eliminated within 15 hours [2].

How long does Armodafinil last?

Whenever the question arises: How long does Armodafinil last? It always means leaving the system completely. When we say the word system, it depicts Blood, Urine,  and Hair.

Armodafinil in Blood and Urine

Armodafinil might last upto 15-20 hours in the Blood and Urine. 

Armodafinil in Hair

It takes 90 days for Armodafinil to be removed entirely from Hair.

Factors Affecting Armodafinil’s Duration-

  1. Dosage– The general recommended dosage for Modafinil is 150mg/day. However, if you take a larger dose, then it might take a longer period to remove the medication.
  1. Age– Age is a significant concern before consuming medicines. After 65 years, the metabolism process takes time and becomes slow with age.
  1. Liver and Kidney Problems– If you have liver and kidney problems, then the duration might be longer, as the metabolism process takes place in the liver and excretion process in the Kidney [3].

How long does Armodafinil take to remove from the system completely?

Armodafinil generally takes 2-3 days to be completely removed from the system once you completely stop taking the medication.

Here’s a chart that might give you a proper picture of Armodafinil’s half-life in every phase [4].

15 hours 65 mg  50%
30 hours 32.5 mg 25%
45 hours 16.25 mg 12.5%
60 hours 8.125 mg 6.25%
75 hours 4.063 mg 3.125%
90 hours  2.031 mg 1.56 %

How do we remove Armodafinil completely from the system?

To completely remove Armodafinil from the system, you can begin detoxing under any medical supervision.   However, when you continuously use the medication and suddenly cut it off, several withdrawal symptoms might be like Nausea, Vomiting, Chills and Fever, Confusion, Sweating, etc.

However, Withdrawal symptoms might vary from patient to patient.  4 Important factors might affect Withdrawal Symptoms. They are –

  1. Age
  2. Metabolism
  3. Organ Function
  4. How long have you been taking Armodafinil? 

Due to this, you should always consult your doctor before detoxifying the medication [3].

Will Armodafinil show up on a drug test?

There are only two body fluids that reliably trace the presence of Armodafinil. The answer to whether Armodafinil will appear on a drug test is Yes. But it depends upon the situation you’re in.

  1. Firstly, you must conduct the tests with your blood and Urine, as already mentioned; it must be intended. 
  2. Secondly, The drug test of the substance will be positive or negative depending upon how long ago Armodafinil was used.

The test that is done to witness Armodafinil’s body is Liquid Chromatography-Mass Spectrometry (LC-MS). The method is all about a technique used for the separation, identification, and quantification of both unknown and known compounds.

How Long Does Armodafinil Stay in Your System: Our Final Verdict

In this context, we’ve tried to cover everything related to how long Armodafinil stays in our system. It should be noted that the duration can vary depending on various factors such as age, dosage, kidney and liver function, etc.


How long does it take for Armodafinil to Wear off?

You can expect Armodafinil to last for 15 hours.

What happens when you stop taking Armodafinil?

When you stop taking this medication, you might have several withdrawal symptoms like nausea, fever, chills, vomiting, etc.

Can I take Armodafinil every day?

Yes, you can take Armodafinil daily.

Can Armodafinil be Addictive?

Yes, Armodafinil can be addictive to some extent, but in a small amount, as it belongs to a Schedule IV Controlled Substance.

Can you take Armodafinil as needed?

No, you cannot take Armodafinil as needed. You should only take the amount as prescribed by your doctor.


  1. Half-life, StatPearls

  2. Pharmacokinetic Profile of Armodafinil in Healthy Subjects, NCBI

  3. How long Does Armodafinil Stay in your System? Therecoveryvillage.

  4. Modafinil and Drug Tests, What You Must Know,

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