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How long does Armodafinil Stay in Your System

Author :

Abhishek Dutta

Post Uploaded Date : October 9, 2023 Last Updated Date : June 22, 2024
Armodafinil generally lasts for about 15 hours, although the duration might vary from patient to patient. It could also take 2-3 days to remove the drug from your system.

Armodafinil is a drug that lasts longer than Modafinil ( a similar drug). If you are wondering how long Armodafinil lasts, you are at the right place. Let’s go through the blog and explore Armodafinil’s Half-life.

What is Armodafinil?

Armodafinil is the R-enantiomer of Modafinil that belongs to the Eugeroic group and helps treat sleep disorders like narcolepsy, obstructive sleep apnea, and shift work sleep disorder.
It is sold under the brand names- Waklert and Artvigil.

How does Armodafinil Work?

The working mechanism of Armodafinil is unclear; however, it has been laid down that Armodafinil works by changing the amount of neurotransmitters like histamine, serotonin, orexin, and dopamine. When inclined, the transmitters enhance focus, memory, and brain functioning.

How Long Does It Take For Armodafinil To Work?

Armodafinil takes 30-60 minutes to start its onset of action after ingesting it with a glass of water. It should be generally taken at the same time every day for better effectiveness.

However, this can vary from person to person [1].

The half-life of Armodafinil

  It is the period that medicine requires to reduce by half. Generally, it takes 4-5 half-lives to remove a medicine by 94-97 %. After 4-5 half-lives are eliminated, the plasma concentrations of a medicine decreases.

After reaching the peak plasma concentrations, the half-life of Armodafinil is eliminated within a maximum of 15 hours [2].

How Long Does Armodafinil Last?

Whenever the question arises: How long does Armodafinil last? It always means leaving the system completely. When we say the word system, it depicts Blood, Urine, and Hair.

Armodafinil in Blood and Urine

Armodafinil might last up to 15-20 hours in the Blood and Urine.  

Armodafinil in Hair

It takes 90 days for Armodafinil to be removed entirely from Hair.

Factors Affecting Armodafinil’s Duration-

  1. Dosage– The general recommended dosage for Modafinil is 150mg/day. However, if you take a larger dose, then it might take a longer period to remove the medication.
  1. Age– Age is a significant concern before consuming medicines. After 65 years, the metabolism process takes time and becomes slow with age.
  1. Liver and Kidney Problems– If you have liver and kidney problems, then the duration might be longer, as the metabolism process takes place in the liver and the excretion process in the Kidney [3].

How Long Does Armodafinil Take To Remove From The System Completely?

Armodafinil generally takes 2-3 days to be completely removed from the system after you stop taking the medication.

Here’s a chart that might give you a proper picture of Armodafinil’s half-life in every phase [4].

15 hours 65 mg  50%
30 hours 32.5 mg 25%
45 hours 16.25 mg 12.5%
60 hours 8.125 mg 6.25%
75 hours 4.063 mg 3.125%
90 hours  2.031 mg 1.56 %

How To Remove Armodafinil Completely From The System?

To completely remove Armodafinil from the system, you can begin detoxing under any medical supervision. However, abruptly stopping the medication can cause several withdrawal symptoms such as nausea, vomiting, chills and fever, confusion, sweating, etc.

Four important factors affecting withdrawal symptoms-

  1. Age
  2. Metabolism
  3. Organ Function
  4. Duration of Armodafinil Use.

Always consult your doctor before detoxifying the medication [3].

Will Armodafinil Show Up On A Drug Test?

Armodafinil shows up on a drug test. But there are two basic situations given below:

  • Firstly, you must conduct the tests with your blood and Urine, as already mentioned; it must be intended. 
  • Secondly, The drug test of the substance will be positive or negative depending upon how long ago Armodafinil was used.

The test that is done to witness Armodafinil’s body is Liquid Chromatography-Mass Spectrometry (LC-MS). The method is all about a technique used for the separation, identification, and quantification of both unknown and known compounds.

How Long Does Armodafinil Stay In Your System: Our Final Verdict

In this context, we’ve tried to cover everything related to how long Armodafinil stays in our system. The duration can vary depending on various factors such as age, dosage, kidney and liver function, etc.


How long does it take for Armodafinil to Wear off?

You can expect Armodafinil to last for 15 hours.

What happens when you stop taking Armodafinil?

When you stop taking this medication, you might have several withdrawal symptoms like nausea, fever, chills, vomiting, etc.

Can I take Armodafinil every day?

Yes, you can take Armodafinil daily.

Can Armodafinil be Addictive?

Yes, Armodafinil can be addictive to some extent, but in a small amount, as it belongs to a Schedule IV Controlled Substance.

Can you take Armodafinil as needed?

No, you cannot take Armodafinil as needed. You should only take the amount as prescribed by your doctor.


  1. Half-life, StatPearls

  2. Pharmacokinetic Profile of Armodafinil in Healthy Subjects, NCBI

  3. How long Does Armodafinil Stay in your System? Therecoveryvillage.

  4. Modafinil and Drug Tests, What You Must Know,

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